6th International Conference on cGMP

cGMP: Generators, Effectors and
Therapeutic Implications

Program

Friday, June 28, 2013

13:00 WELCOME COFFEE
14:00 Harald Schmidt,
Maastricht		 Welcome to Erfurt
Session 1
Therapeutic
Breakthroughs		 Chair:
Harald Lapp, Erfurt
Johannes-Peter Stasch, Wuppertal
14:10 Horng Chen,
Rochester		 Chronic NP protein therapeutics
14:35 Loek Van Heerebeek,
Amsterdam		 Increased nitrosative/oxidative stress lowers myocardial protein
kinase G activity in heart failure with preserved ejection fraction
15:00 Ardehir Ghofrani,
Giessen		 PATENT and CHEST Phase III trials with riociguat
15:25 Kazuwa Nakao,
Kyoto		 Lessons from tissue-specific KO of CNP/GC-B System
- everlasting challenge to clinical application
15:50–16:20 COFFEE BREAK
Session 2
GWAS and
cGMP Function I		 Chair:
John Burnett, Rochester
Kenneth Bloch, Boston
16:20 Christopher Newton-Cheh,
Boston		 What have genome-wide association studies taught us about cGMP and blood pressure regulation?
16:45 Heribert Schunkert,
München		 Genetic variants in guanylyl cyclase and phoshodiesterase affecting coronary disease risk
17:10 Valentina Cannone,
Rochester		 Genetic variants of ANP and cardiometabolic protection
Session 3
GWAS and
cGMP Function II		 Chair:
Ferid Murad, Houston
Christopher Newton-Cheh, Boston
17:35 Manu Buys,
Boston		 Genetic modifiers of hypertension in sGC-deficient mice
18:00 Martin Wilkins,
London		 Pulmonary vascular adaptation to high-altitude living
18:25 Kenneth Bloch,
Boston		 MicroRNA miR-425 is a negative regulator of atrial natriuretic peptide
18:50-20:00
Session 4
Poster Visit		 SNACK AND REFESHMENTS
WINE AND BEER
Evening Lecture Chair:
Günter Schulz, Berlin
20:00–21:00 Franz Hofmann,
München		 cGMP kinase: past, present and future

Saturday, June 29, 2013

Session 5
sGC/GK Structure and Function		 Chair:
Doris Kösling, Bochum
Michaela Kuhn, Würzburg
08:30 Michael Marletta,
La Jolla		 Conformational changes involved in sGC activation
08:55 Lincoln Potter,
Minneapolis		 A twenty year journey to understand how ATP activates guanylyl cyclase A and B
09:15 Franziska Seeger,
Baltimore		 Soluble Guanylate Cyclase crystal clear: 1st crystal structure of the wild-type human heterodimeric sGC catalytic domains
09:30 Opher Gileadi,
Oxford		 Crystal structures of the catalytic domains of human sGC
09:45 Choel Kim,
Houston		 Structures of human PKG reveal cGMP-selective activation mechanisms
10:10-10:40 COFFEE BREAK
Session 6
sGC/GK Structure
and Function		 Chair:
Michael Mendelsohn, New Jersey
Harald Schmidt, Maastricht
10:40 Mary Struthers,
New Jersey		 Targeting native and apo-sGC
11:05 Dennis Stuehr,
Cleveland		 Mechanisms driving heme insertion into apo-sGC during its maturation in cells
11:30 Philip Eaton,
London		 Redox signalling in cardiac physiology and pathology
11:55 Hunter Champion,
Pittsburgh		 New mechanisms of normoxic and hypoxic cGMP signaling mediated by the nitrite anion
12:20 Annie Beuve,
Newark		 Thiol-redox proteins interact with sGC and modulate its activity
12:45 Emily Tsai,
Philadelphia		 Chronic beta-adrenergic blockade prevents volume overload-induced re-localization and oxidation of sGC
13:10-14:30
Session 7
Poster Visit		 SNACK AND REFESHMENTS
15:00-16:00 CATHEDRAL CONCERT
Philharmonic Orchestra, Dom zu Erfurt
16:00-18:00 ERFURT VISIT
Guided walking tour through the historic Erfurt
18:00-20:00 SNACK AND REFESHMENTS
Ferid Murad
Lecture		 Chair:
Michael Marletta,
La Jolla
20:00–21:00 Mark T Nelson,
Burlington		 Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function

Sunday, June 30, 2013

Session 8
Other Functions
of cGMP		 Chair:
Kazuma Nakao, Kyoto
Ulrich Walter, Mainz
08:30 Sheila Collins,
Orlando		 Natriuretic peptides and fat metabolism
08:55 Alexander Pfeifer,
Bonn		 Role of cGMP in fat and metabolism
09:15 Renate Pilz,
La Jolla		 Non-genomic thyroid hormone signaling through NO/cGMP/PKGII
09:40 Marlies Knipper,
Tübingen		 cGMP-Prkg1 signaling PDE5 inhibition shelter cochlear hair cells and hearing function
10:05 Scott Waldman,
Philadelphia		 GUCY2C at the intersection of obesity and colorectal cancer
10:30-11:00 COFFEE BREAK
Session 9
sGC/GK Structure
and Function		 Chair:
Franz Hofmann, München
Jens Schlossmann, Regensburg
11:00 Andreas Friebe,
Würzburg		 Cell type-specific knock out models to unravel NO/cGMP signalling in the cardiovascular system
11:25 Dieter Saur,
München		 Interstitial cells of Cajal link excitatory and nitrergic inhibitory neurotransmission with slow-wave activity in the intestine
11:50 Ursula Seidler,
Hannover		 cGMP-dependent kinase 2, Na+/H+ regulatory factor 2, and Na+/H+ exchanger isoform 3 assemble within lipid rafts in murine small intestinal brush border membrane
12:15 Andreas Papapetropoulos,
Patras		 NO-H2S interactions involve cGMP
12:40-14:00
Session 10
Poster Visit		 SNACK AND REFESHMENTS
Session 11
cGMP and Anti-Proliferation		 Chair:
Ferid Murad, Washington
Scott Waldman, Philadelphia
14:00 Motofumi Kumazoe,
Kyushu		 67-kDa laminin receptor and cGMP induced cancer-selective apoptosis
14:25 Kenji Kangawa,
Osaka		 A novel physiological significance of natriuretic peptides in cancer metastasis
14:50 Michaela Kuhn,
Würzburg		 Dual actions of ANP on endothelial permeability
15:15 – 15:45 COFFEE BREAK
Session 12
Poster Presentation		 Chair:
Adrian Hobbs, London
Annie Beuve, Newark
15:45–17:00 12 selected posters Each candidate may talk for 3 minutes and show up to 3 slides or overheads and allow for 2 minutes question time

5 minute rapid fire oral presentations of selected posters
Session 13
Upcoming Topics		 Chair:
Andreas Papapetropoulos, Patras
Gilberto De Nucci, São Paulo
17:00 Roland Seifert,
Hannover		 Pseudomonas aeruginosa ExoY, a cyclic GMP- and cyclic UMP-generating nucleotidyl cyclase
17:25 Elizabeth Boon,
Stony Brook		 Nitric oxide regulated cyclic di-GMP signaling
17:45 Sergei Rybalkin,
Seattle		 Differential effects of PDE5 inhibitors on cardiac dysfunction in the MDX mouse model of Duchenne Muscular Dystrophy
Session 14
Committee Meetings
18:00 – 18:20 Poster Prize Committee Selected out of poster presentations
Young Investigator Award Selected out of all presentations
19:00 COCKTAIL AND DINNER AT PALMENHAUS ERFURT
AWARD CEREMONY
FAREWELL PARTY
Postersessions
  1. Marina Aleksinskaya, Jacques Duijs, Jennifer Veth, Bettina Husen, Dania Reiche, Daniel Jasserand, Jo De Mey, Ton Rabelink, Anton Jan van Zonneveld
    Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model

  2. Camila Almeida, Claudio C Werneck, Cristina C Vicente, Fábio T Costa, Fernando F Costa,Nicola Conran
    Hydroxyurea reduces leukocyte interactions with the vessel wall in a haemolytic mouse model via a possible NO/cGMP-mediated effect

  3. Jenna Bailey, Sayqa Arif, Jorge Mascaro, Robert Bonser, Michael P Frenneaux, Melanie Madhani
    Effect of nitrite treatment on endothelial nitric oxide synthase in human left ventricle biopsy

  4. Aileen Balkow, Johanna Jagow, Ana Kilic, Alexander Pfeifer
    A possible crosstalk between cGMP pathway and Activin receptor-like kinase 7 (Alk7) in adipocytes

  5. Corina Becker, Reiner Frey, Sigrun Unger, Dirk Thomas, Michael Reber, Gerrit Weimann, Hartmut Dietrich, Erich R Arens, Wolfgang Mueck
    Pharmacokinetic interaction of ketoconazole, clarithromycin, and midazolam with riociguat

  6. Corina Becker, Reiner Frey, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann, Wolfgang Mueck
    Effects of omeprazole and AlOH/MgOH on riociguat absorption

  7. Corina Becker, Reiner Frey, Christiane Hesse, Sigrun Unger, Michael Reber, Wolfgang Mueck
    Absorption behavior of riociguat: bioavailability, food effects, and dose-proportionality

  8. Noomen Bettaga, Andreas Friebe, Ronald Jäger
    Role of NO-sensitive guanylyl cyclase in angiogenesis and arteriogenesis

  9. Ka Bian, Alex Sotolongo, Haijie Xiao, Dandan Zhang, Jun Liu, Ferid Murad
    NO-cGMP signalling and cancer therapy

  10. Robert Blanton, Angela Lane, Mark Aronovitz, Guang-Rong Wang, Robrecht Thoonen, Roger Davis, Michael Mendelsohn, David Kass, Richard Karas
    Identification of protein kinase G I alpha interacting proteins as potential targets to prevent cardiac remodeling

  11. George Britton, Iraida Sharina, Emil Martin
    G-protein signaling modulator 1 is a modifier of sGC-dependent vascular response

  12. Heike Burhenne, Sarah Tschirner, Roland Seifert, Volkhard Kaever
    Identification and quantitation of 2´,3´-cGMP in murine tissues

  13. Darren E Casteel, Raphaela Schwappacher, Hema Rangaswami, Jacqueline Su-Yuo
    cGMP-dependent protein kinase Iβ phosphorylates and regulates the function of the actin/myosin-associated protein caldesmon

  14. Ying-Chi Chao, Heinz Breer, Yuh-Charn Lin, Chih-Cheng Chen, Joerg Fleischer, Ruey-Bing Yang
    Receptor guanylyl cyclase-G is a novel thermosensor in Grueneberg ganglion neurons involved in coolness-induced ultrasonic distress calls in mice

  15. Mikolaj Chrominski, Dorota Gryko, Iraida Sharina, Emil Martin
    Synthesis and evaluation of bifunctional sGC regulators

  16. Eleonora Corradini, Pepijn P Burgers, Michael Plank, Albert JR Heck, Arjen Scholten
    A tissue based chemical proteomics screen to identify novel G-kinase associated proteins (GKAPs)

  17. Eleonora Corradini, Robert Feil, Albert JR Heck, Arjen Scholten
    Defining the molecular targets of cerebellar PKG by quantitative (phospho)proteomics in a knock-out mouse model

  18. Gilberto de Nucci, Luiz Osorio Leiria, Fábio Henrique da Silva, Eduardo C Alexandre, Marina Calixto, Fabíola Zakia Mónica, Edson Antunes
    The soluble guanylyl cyclase activator BAY 60-2770 ameliorates detrusor dysfunction in obese mice

  19. Sandeep Dhayade, Susanne Feil, Christoph Griessinger, Manfred Kneilling, Birgit Schittek, Robert Feil
    A novel role of the natriuretic peptide/cGMP/cGKI pathway in melanoma cells

  20. Jennifer Etzrodt, Linda S Hoffmann, Andreas Friebe, Alexander Pfeifer
    The soluble guanylyl cyclase stimulator BAY 41-2272 increases differentiation and function of brown adipocytes

  21. Reiner Frey, Corina Becker, Sigrun Unge, Anja Schmidt, Georg Wensing, Wolfgang Mueck
    Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with hepatic impairment

  22. Reiner Frey, Corina Becker, Sigrun Unger, Anja Schmidt, Georg Wensing, Wolfgang Mueck
    Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with renal impairment

  23. Reiner Frey, John Lettieri, Andrea Nadel, Corina Becker, Wolfgang Mück
    Effects of age and gender on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat

  24. Anja Glöde, Ana Kilić, John C Burnett, Alexander Pfeifer
    Guanylyl cyclase-B plays an important role in adipogenesis and “browning” of white fat

  25. Constantinos Glynos, Dimitris Toumpanakis, Zongmin Zhou, Peter Brouckaert , Theodoros Vassilakopoulos, Andreas Papapetropoulos
    Soluble guanylyl cyclase as a therapeutic target in chronic obstructive pulmonary disease (COPD)

  26. Konrad R Götz, Viacheslav O Nikolaev
    PDE3 is the major cGMP-PDE in adult mouse ventricular cardiomyocytes

  27. Dieter Groneberg, Anna Schlembach, Andreas Friebe
    Cardiovascular response to NO donors in mice deficient in NO-GC

  28. Staffan Hildebrand, Katrin Zimmermann, Daniela Wenzel, Bernd K Fleischmann, Alexander Pfeifer
    The role of VASP in cGMP-mediated vascular smooth muscle relaxation

  29. Berthold Hocher, Fabian Heunisch, Gina-Franziska von Einem, Markus Alter, Yvonne Keim, Johannes-Peter Stasch
    Urinary cGMP concentrations after exposure to radio-contrast media in patient at risk for contrast media induced nephropathy (CIN) predicts 90-day morbidity and mortality

  30. Linda Hoffmann, Axel Kretschmer, Bettina Lawrenz, Andreas Hucke, Berthold Hocher, Johannes-Peter Stasch
    Chronic activation of heme free soluble guanylate cyclase leads to cardio-renal protection in experimental hypertension

  31. Laurinda A Jaffe, Jeremy R Egbert, Leia C Shuhaibar, Lai Wen, Martin Thunemann, Robert Feil, Viacheslav Nikolaev, Jerid W Robinson, Lincoln R Potter
    Cyclic GMP-mediated intercellular communication in mammalian ovarian follicles

  32. Ana Kilić, Thorsten Gnad, Linda S Hoffmann, Alexander Pfeifer
    Phosphodiesterase 5 is main regulator of brown adipocyte differentiation

  33. Jeong Joo Kim, Eduardo Sanabria Figueroa, Eugen Franz, Daniela Bertinetti , Friedrich Herberg, Choel Kim
    Crystal structures of the carboxyl cGMP binding domain of plasmodium falciparum cGMP-dependent protein kinase reveals a novel salt bridge crucial for activation

  34. Sabine Klein, Barbara Seidler, Anna Kettenberger, Andrei Sibaev, Robert Feil, Franz Hofmann, Jean-Marie Vanderwinden, Hans-Dieter Allescher, Michael Schemann, Martin A Storr, Roland M Schmid, Günter Schneider, Dieter Saur
    Interstitial cells of Cajal plasticity rather than regeneration restores slow-wave activity and enteric neurotransmission upon acute damage

  35. Michaela Kuhn,Thomas Premsler, Ruey-Bing Yang, Thomas D Mueller, Birgit Gaßner, Heike Oberwinkler, Sabine E Hannema, Hermine A van Duyvenvoorde, Ferdinand Roelfsema, Gijs WE Santen, Timothy Prickett, Sarina G Kant, Annemieke JMH Verkerk, André G Uitterlinden, Eric Espiner, Claudia AL Ruivenkamp, Wilma Oostdijk, Alberto M Pereira, Monique Losekoot, Jan M Wit
    A bone overgrowth disorder due to a gain-of-function mutationin the kinase homology domain of guanylyl cyclase B, the receptor for CNP

  36. Friedericke Langhauser, Annegret Hauck, Kim Radermacher, Johannes-Peter Stasch, Christoph Kleinschnitz, Harald HHW Schmidt
    Increases survival by apo-sGC activation via post-stroke blood brain barrier stabilisation and anti-inflammation

  37. Barbara Lies, Dieter Groneberg, Dieter Saur, Andreas Friebe
    Localization and function of NO-GC in the murine gastrointestinal and lower urinary tract

  38. Soo Ghim Lim, S Jeson Sangaralingham, Syed Ameenuddin, Fernando L Martin, Xu Wen Ng, Ying Ying Huang, Subbu S Venkatraman, John C Burnett Jr, Horng H Chen
    A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction

  39. Elaine Liong, Christopher Graul, Samuel Rivers, Marco Kessler, Gerhard Hannig, Inmaculada Silos-Santiago
    Metabolic fate of orally administered cGMP in rats

  40. Florian Loga, Katrin Domes, Marc Freichel, Veit Flockerzi, Alexander Dietrich, Lutz Birnbaumer, Franz Hofmann, Jörg W Wegener
    Evidence for functional coupling of cGMP/cGKI signalling and TRPC channels in endothelium but not in vascular smooth muscle

  41. Robin Lorenz, Eui-Whan Moon, Gilbert Y Huang, Albert S Reger, Jeong J Kim, Eugen Franz, Daniela Bertinetti, Choel Kim, Friedrich W Herberg
    Transforming PKA into PKG – a structure-function approach to understand cyclic nucleotide selectivity

  42. Emil Martin, Eva Golunski, Iraida Sharina
    Alternative splicing of α1 and β1 sGC genes is altered in aortic disease

  43. Paul M McKie, Alessandro Cataliotti, Tomoko Ichiki, S Jeson Sangaralingham, Horng H Chen, John C Burnett Jr
    M-atrial natriuretic peptide and nitroglycerin in experimental acute hypertensive heart failure: differential actions of two cGMP activating therapeutics

  44. Andrea Mietens, Gerrit Eichner, Sabine Tasch, Caroline Feuerstacke, Ingrid Schneider-Hüther, Dieter Müller, Ralf Middendorff
    Video microscopy as a tool to visualize cGMP effects on contractility and sperm transport in seminiferous tubules and the epididymal duct

  45. Marion Mussbacher, Karoline Pail, Gerald Wölkart, Günter Hämmerle, Alois Lametschwandtner, Rudolf Zechner, Bernd Mayer, Astrid Schrammel
    Endothelial dysfunction in adipose triglyceride lipase deficiency: role of perivascular adipose tissue

  46. Hitoshi Nakagawa, Katharina Völker, Heike Oberwinkler, Birgit Gaßner, Charlotte Dienesch, Sandra Umbenhauer, Hideo A Baba, Stefan Frantz, Michaela Kuhn
    The good and the ugly: ANP antagonizes the deleterious effects of aldosterone in hypertensive cardiac remodeling

  47. Yasuaki Nakagawa, Toshio Nishikimi, Naoto Minamino, Chinatsu Yamada, Kazuhiro Nakao, Takeya Minami, Yoshihiro Kuwabara, Hideyuki Kinoshita, Shinji Yasuno, Kenji Ueshima, Koichiro Kuwahara, Kenji Kangawa, Kazuwa Nakao
    The effects of super-flux (high performance) dialyzer on the plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-terminal proBNP in end-stage renal disease patients on dialysis

  48. Kazumasa Nakao, Akihiro Yasoda, Kenji Osawa, Toshihito Fujii, Eri Kondo, Noriaki Koyama, Naotetsu Kanamoto, Masako Miura, Koichiro Kuwahara, Haruhiko Akiyama, Kazuhisa Bessho, Kazuwa Nakao
    Impact of local CNP/GC-B system in growth plates on endochondral bone growth

  49. Regina Neubauer, Andrea Neubauer, Gerald Wölkart, Christine Schwarzenegger, Barbara Lang, Kurt Schmidt, Michael Russwurm, Doris Koesling, Antonius CF Gorren, Astrid Schrammel, Bernd Mayer
    Potent inhibition of nitroglycerin bioactivation by diphenyleneiodonium (DIP)

  50. Toshio Nishikimi, Yasuaki Nakagawa, Naoto Minamino, Masashi Ikeda, Toshihiko Ishimitsu, Chinatsu Yamada, Kazuhiro Nakao, Takeya Minami, Yoshihiro Kuwabara, Hideyuki Kinoshita, Koichiro Kuwahara, Kenji Kangawa, Kazuwa Nakao O-glycosylated pro-B-type natriuretic peptide is cleaved intracellularly by furin in ventricular and atrial myocytes: importance of the distance between the O-glycosylation and cleavage sites
  51. Takashi Nojiri, Hiroshi Hosoda, Toru Kimura, Kenji Kangawa
    ANP/GC-A signaling attenuates tissue injury by cisplatin

  52. Takashi Nojiri, Hiroshi Hosoda, Shin Ishikane, Toru Kimura, Kenji Kangawa
    ANP/GC-A signaling attenuates pulmonary metastasis of B16 melanoma enhanced by lipopolysaccharide or angiotensin-II

  53. Kentaro Otani, Takeshi Tokudome, Ichiro Kishimoto, Yuanjie Mao, Kenichi Yamahara, Kazuwa Nakao, Kenji Kangawa
    Protective role of endogenous cardiac natriuretic peptide/GC-A system on the maternal heart during the postpartum period

  54. Nisha Perez, Christopher Graul, Peter Germano, Erik Solberg, Samuel Rivers, Robert Solinga, Joel Moore, Gerhard Hannig, Ada Silos-Santiago, Robert Busby, Daniel Zimmer
    Determination of cGMP levels in rodent tissues following oral dosing of a soluble guanylate cyclase stimulator

  55. Cora Reiss, Igor Mindukshev, Verena Bischoff, Stepan Gambaryan, Ulrich Walter
    Platelet inhibitory effects of the NO independent sGC stimulator riociguat

  56. Rebecca Ritchie, Jennifer Irvine, Nga Cao, Swati Gossain, Amy Alexander, Jane Love, Chengxue Qin, John D Horowitz, Barbara K Kemp-Harper
    The nitroxyl donor isopropylamine-NONOate elicits soluble guanylyl cyclase-dependent antihypertrophic actions: comparison of the potential therapeutic advantages of HNO over NO•

  57. Rebecca Ritchie, Kai Yee Chin, Chengxue Qin, Nga Cao, Barbara Kemp-Harper, Owen Woodman
    Soluble guanylyl cyclase mediates concomitant coronary vasodilator and positive inotropic actions of the HNO donor Angeli's salt in the intact rat heart

  58. Olena Rudyk, Alkystis Phinikaridou, Oleksandra Prysyazhna, Joseph R Burgoyne, Rene Botnar, Philip Eaton
    Protein kinase G oxidation contribute to hypotension and organ injury during sepsis

  59. Corina Russwurm, Doris Koesling, Michael Russwurm
    In striatum phosphodiesterase 10A is part of a synaptic signalling complex

  60. Abhishek Sanyal, Didier Lochmatter, Anne Preußner, Alexander Pfeifer
    Influence of PKG on insulin signalling and GSK3 phosphorylation in SH-SY5Y cells

  61. Elisabeth Schinner, Andrea Schramm, Frieder Kees Franz Hofmann, Jens Schlossmann
    Suppression of kidney fibrosis by cGMP-dependent protein kinase I

  62. Erich Schneider, Maike Kuhn, Daniel Reinecke, Sabine Wolter, Heike Burhenne, Volkhard Kaever, Roland Seifert
    Fishing for elusive cCMP-degrading phosphodiesterases

  63. Andrea Schramm, Elisabeth Schinner, Jens Schlossmann
    Function of cGMP-dependent protein kinase II in volume expansion-induced diuresis

  64. Astrid Schrammel, Marion Mussbacher, Gerald Wölkart, Heike Stessel, Günter Hämmerle, Wael Al Zoughbi, Gerald Höfler, Alois Lametschwandtner, Rudolf Zechner, Bernd Mayer
    Endothelial dysfunction in a mouse model of human neutral lipid storage disease

  65. Marton I Siklos, Ronak P Gandhi, Rui Xiong, Isaac T Schiefer, Vladislav Litosh, Lawren VandeVrede, Gregory RJ Thatcher
    Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway

  66. Alex Sotolongo, Ka Bian, Ferid Murad
    Genetic silencing of sGC β1 in cancer: role of epigenetic regulation

  67. Sindhuja Sridharan, R Manjunatha Kini
    Krait natriuretic peptide (KNP): a non-classical NP

  68. Julia Straubinger, Peter Ruth, Robert Lukowski
    Cardiac cGMP/cGMP-dependent protein kinase I signalling requires cysteine-rich LIM-only protein 4 (CRP4) to oppose angiotensin II induced hypertrophy and fibrosis

  69. Hariharan Subramanian, Ulrich Walter, Stepan Gambaryan
    Differential regulation of platelet inhibition by cGMP- and cAMP-dependent protein kinases

  70. Boris Tchernychev, Sarah Jacobson, Caroline Kurtz, Mark Currie, Inmaculada Silos-Santiago
    Linaclotide induces secretion of cGMP from mouse colonic epithelium

  71. Gohar Ter-Avetisyan, Fritz G Rathjen, Hannes Schmidt
    Receptor guanylyl cyclase B-mediated cGMP signalling controls axon bifurcation of cranial sensory ganglion neurons at the embryonic hindbrain

  72. Gregory RJ Thatcher, Jia Luo, Lawren VandeVrede, Zhihui Qin, Sue Lee, Ramy Abdelhamid, Brian M Bennett, Mary Jo LaDu, Leon Tai, John Larson
    NO/cGMP/pCREB re-activation reverses cognition deficits and attenuates amyloid-β neuropathology in transgenic models of Alzheimer’s disease

  73. Takeshi Tokudome, Kentaro Otani, Ichiro Kishimoto, Yuanjie Mao, Kazuwa Nakao, Kenji Kangawa
    Endothelial GC-A can be a therapeutic target for metabolic syndrome

  74. Raghavan Vallur, Hubert Kalbacher, Jana Krauß, Robert Feil
    Phospho-specific antisera to monitor N-terminal autophosphorylation of cGMP-dependent protein kinase type I

  75. Benjamin Vandendriessche, Elke Rogge, Vera Goossens, Peter Vandenabeele, Johannes-Peter Stasch, Peter Brouckaert, Anje Cauwels The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems
  76. Lai Wen, Martin Thunemann, Susanne Feil, Matthias Hillenbrand, Angelos Vachaviolos, Thomas Ott, Xiaoxing Han, Dai Fukumura, Rakesh K Jain, Cor de Wit, Michael Russwurm, Robert Feil
    Analysis of cGMP signalling with transgenic mice expressing FRET-based cGMP sensors

  77. Franziska Werner, Katharina Völker, Claus-Jürgen Scholz, Margarethe Goebel, Michael Seimetz, Baktybek Kojonazarov, Kai Schuh, Bhola K Dahal, Ralph T Schermuly, Heike Oberwinkler, Birgit Gaßner, Michaela Kuhn
    Genes involved in pulmonary hypertension of mice with endothelial-specific ablation of guanylyl cyclase A

  78. Stefanie Wolfertstetter, Elisabeth Schinner, Franz Hofmann, Jens Schlossmann
    Identification of cCMP binding and activated proteins

  79. Sabine Wolter, Marina Golombek, Frank Schwede, Hans-Gottfried Genieser, Stefan Dove, Roland Seifert
    Activation profile of cGMP-dependent protein kinase Iα

  80. Lin Zhang, Robert Lukowski, Florian Gaertner, Michael Lorenz, Kyle R Legate, Katrin Domes, Elisabeth Angermeier, Franz Hofmann, Steffen Massberg
    Anti-interleukin-6 therapy for treatment of high platelet counts in cGMP-dependent protein kinase I gene-targeted mice

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