Friday, June 15, 2007


14:00 Franz Hofmann, München Welcome
Plenary Talk Chair: Franz Hofmann, München

14:10 Joachim Schultz,
Characterization of tandem GAF domains of PDEs

Session 1
Cardiopulmonary Pharmacology

Chair: John Burnett, Rochester
Johannes-Peter Stasch, Wuppertal
14:40 Oleg Evgenov,
Therapeutic potential of soluble guanylate cyclase agonists in pulmonary hypertension
15:00 Ralph Schermuly,
sGC stimulators in experimental pulmonary hypertension


Martin van Eickels,
Role of sGC activator HMR 1766 in cardiovascular disease
15:40 Barbara Kemp-Harper,
Oxidised sGC: a novel therapeutic target in the vasculature
16:00 David Kass,
Molecular modulators of cardiac stress targeted by PDE5 inhibition
16:20 Adrian Hobbs,
Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension
16:40 – 17:10 COFFEE BREAK
Session 2
Clinical breakthroughs: Heart & Lung
Chair: Warren Zapol, Boston
John Parker, Toronto
17:10 Ardeschir Ghofrani,
Clinical results with the sGC stimulator BAY 63-2521 in patients with pulmonary hypertension
17:30 Harald Lapp,
Clinical results with the sGC activator BAY 58-2667 in patients with acute decompensated heart failure
17:50 Mark Semigran,
The emerging role of PDE5 inhibition in heart failure
18:10 Veselin Mitrovic,
Bad Nauheim
Clinical trials with urodilation in patients with acute decompensated heart failure
18:30   Tommaso Gori,
The NO-cGMP axis in endothelial ischemia and ischemic preconditioning
18:50 Vicente Felipo,
Restoration of learning in hepatic encephalopathy by pharmacological manipulation of cGMP levels in brain
Session 3

Guided Posters

Molecular Mechanisms Chair: Günter Schultz, Berlin


cGMP assays and reporters Chair: Rodolphe Fischmeister, Paris


Platelets/VSMC Chair: Jens Schlossmann, Regensburg


Evening Lecture Chair: Günter Schultz, Berlin

20:00 John Burnett,
Modulating cGMP in heart failure


Saturday, June 16, 2007


Session 4
Genetic Models
Chair: Ferid Murad, Houston
Renate Pilz, San Diego
08:00 Franz Hofmann,

Analysis of mice with genetic modifications of PKG I

08:20 Peter Brouckaert,

Transgenic mice with a NO-insensitive soluble guanylate cyclase

08:40 Michaela Kuhn,

Guanylyl cyclase-A mediated endothelial actions of natriuretic peptides are critically involved in postischemic reperfusion

09:00 Ruey-Bing Yang,

Receptor guanylyl cyclase-G-deficient mice are protected against renal ischemia-reperfusion injury by preventing apoptosis and inflammation

09:20 Robert Feil,
New mouse models for the analysis of cGMP signalling
09:40 John Garthwaite,
A mouse (and chips) model for NO-activated guanylyl cyclase
10:00-10:30 COFFEE BREAK
Session 5
Reporters and cGMP Detection
Chair: Harald Schmidt, Melbourne
John Catravas, Georgia
10:30 Martin Lohse,
Rapid monitoring of intracellular cGMP
10:50 Lydia Nausch,
FlincGs: novel, non-FRET cGMP biosensors with nanomolar sensitivity for NO-induced signaling
11:10 Rodolphe Fischmeister,
cGMP compartments in cardiac myocytes
11:30 Michael Russwurm,
Design and characterization of FRET-based cGMP indicators
11:50 Elke Butt,
Specificity of commonly used cyclic nucleotides with PKA, PKG and Epac-implementing microcalorimetry to determine PDE activities
12:10 Robert Blanton,
In vivo evidence that cyclic GMP-dependent protein kinase G type I α mediates an anti-hypertrophic pathway in the heart
Session 6
Guided Poster Session
Heart/Lung Chair: Mark Semigran, Boston


Cardiovascular/ Urology Chair: Gilberto De Nucci, Sao Paulo


CNS Chair: Vicente Felipo, Valencia


13:30-17:00 DRESDEN VISIT
Guided visit of the Semper Opera followed by a guided walking tour of the historic Dresden.

Ferid Murad Lecture

Chair: Ferid Murad, Houston



Michael Marletta,
A life-time achievement lecture in cGMP: “Molecular steps in sGC activation”
Session 7
Chair: Doris Koesling, Bochum
Jackie Corbin, Tennessee

Delphine Behr-Roussel,

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses endothelial dysfunction and oxidative stress associated with the metabolic syndrome
19:05 Sergei Rybalkin,
Phosphorylation of cAMP hydrolyzing PDE (PDE3A) by cGMP-dependent protein kinase (PKG) in human platelets
19:25 Jackie Corbin,
Negative feedback control of the nitric oxide/cGMP pathway in smooth muscle
19:45 Krassimira Ivanova,
Melanocytes: interface of cell biology and pathobiology with a focus on nitric oxide and cGMP signaling


Sunday, June 17, 2007


Session 8
Guanylyl Cyclases
Chair: Michael Marletta, Berkeley
Andreas Papapetropoulos, Patras
Plenary Talk
Kazuwa Nakao,
Natriuretic peptides: from bench to bedside
08:30 Michael Wolin,
New York

Influence of heme metabolism and redox regulation of sGC in the control of vascular function

08:50 Werner Müller-Esterl,
Oxidative stress induces CHIP-mediated ubiquitination and roteasomal degradation of soluble guanylyl cyclase
09:10 John Catravas,
Hsp90 and sGC-mediated vasorelaxation
09:30 Christiane Rothkegel,

Insights into activation and dimerization of sGC

09:50 Focco van den Akker,
Structural insights into sGC
10:10 Emil Martin,
Dynamic ligand exchange as mechanism for sGC selectivity, NO activation and its reversal
10:30-11:00 COFFEE BREAK
Session 9
cGMP Signalling & Effectors
Chair: Franz Hofmann, München
Werner Müller-Esterl, Frankfurt
11:00 Xin-Yun Huang,
New York
A new Rac-cGMP signaling pathway

Michael Mendelsohn,

PKG in vascular development and disease
11:40 Robert Lukowski,
Vascular remodelling in the absence and presence of cGKI
12:00 Andreas Papapetropoulos,
sGC activation promotes angiogenesis


Paula Pifarré,
NO-sensitive guanylyl cyclase β1 subunit interacts with chromosomes during mitosis: novel role in the regulation of chromatin condensation
Session 10
Guided Poster Session
sGC/PKG Chair: Michaela Kuhn, Würzburg


Endothelium Chair: Elke Butt, Würzburg


Others Chair: Annie Beuve, Newark


Session 11
Functions of cGMP: CNS
Chair: Thomas Kleppisch, München
Frank Menniti, Groton
13:40 Doris Koesling,
Functional roles of isoforms of NO-sensitive guanylyl cyclase
14:00 Boris Hogema,
cGK II regulation of NHE3 and CFTR: role of PDZ domain proteins
14:20 Marla Sokolowski,
cGMP kinase and food-related behaviours
14:40 Agne Stonkute,
cGMP signaling and bifurcation of sensory axons at the dorsal root entry zone of the spinal cord
15:00 Frank Menniti,
Regulation of cGMP by phosphodiesterases (PDEs) in the central nervous system
Session 12
Fuctions of cGMP: Platelets
Chair: Ulrich Walter, Würzburg
Robert Feil, Tübingen
15:20 Jens Schlossmann,
Signaling of NO/cGMP via IRAG
15:40 Stephan Gambaryan,
NO/cGMP/PKG pathway in platelets: stimulatory or inhibitory?
16:00 Steffen Massberg,
Increased aggregation of platelets lacking cGKI/PKG
16:20-16:50 COFFEE BREAK
Session 13
Poster Prize Session
Chair: Barbara Kemp-Harper, Melbourne
Adrian Hobbs, London
16:50-17:20 NN Each candidate may talk for 3 min and show up to 3 slides or overheads and allow for 2 min question time
Session 14 Committee Meetings  
17:20-17:45 Poster Prize Committee Selected out of poster presentations
17:20-17:45 Young Investigator Award Selected out of all oral presentations
17:20-18:00 Nomenclature Committee Chair: John Garthwaite, London
19:00 COCKTAIL AND DINNER at Ball- and Brauhaus Watzke

Award Ceremony




Poster Session
  1. Silvana Andric, Natasa Stojkov, Marija Janjic, Stanko Stojilkovic, Tatjana Kostic
    cGMP signaling pathway is involved in Leyding cell stress response
  2. Reshma S Baliga, Lan Zhao, Martin R Wilkins, Raymond J MacAllister, Adrian J Hobbs
    Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDEInhibitors: a novel combination therapy for pulmonary hypertension?
  3. María Antonia Baltrons, Paula Pifarré, María Teresa Berciano, Miguel Lafarga, Agustina García
    LPS-induced down-regulation of NO-sensitive guanylyl cyclase in astrocytes occurs by proteasomal degradation in nuclear bodies
  4. Fernando R Báu, Cleber E Teixeira, Gilberto De Nucci, Edson Antunes
    Relaxant effect of BAY 41-2272 in the rabbit isolated detrusor smooth muscle (DSM): involvement of cGMP-independent mechanisms
  5. Delphine Behr-Roussel, Alexandra Oudot, Sandrine Compagnie, Diana Gorny, Olivier Le Coz, Jaques Bernabé, Chris Wayman, Laurent Alexandre, Francois Giuliano
    Daily treatment with sildenafil, an inhibitor of cGMP-dependent phosphodiesterase, normalizes the exaggerated hemodynamic response to norepinephrine in fructose-fed rats
  6. Brian Bennett, James Reynolds, Greg Thatcher
    Selective activation of hippocampal guanylyl cyclase by a novel NO mimetic nitrate ester
  7. Matteo Beretta, Alexander Kollau, Michael Russwurm, Doris Koesling, Wing Ming Keung, Kurt Schmidt, Bernd Mayer
    Activation of soluble guanylate cyclase in the presence of purified human aldehyde dehydrogenases
  8. Dominik Bernhard, Franz Hofmann, Jens Schlossmann
    Relaxation of vascular smooth muscle by the cGMP-kinase substrate IRAG
  9. Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Harald Lapp, Johannes-Peter Stasch, John C Burnett, Jr
    Targeting heme-oxidized soluble guanylate cyclase with BAY 58-2667 in experimental heart failure
  10. Liliana Castro & Rodolphe Fischmeister
    Opposite effects of cGMP-dependent protein kinase on cGMP production by soluble andparticular guanylyl cyclase in adult ventricular myocytes
  11. Mário A Claudino, Juliana S Baracat, Enilton A Camargo, Fernanda BM Priviero, Cleber E Teixeira, Gilberto de Nucci, Angelina Zanesco, Edson Antunes
    Run training ameliorates the established erectile dysfunction in rats under long-term nitric oxide (NO) blockade
  12. Lisa C Costello-Boerrigter, Guido Boerrigter, Gail J Harty,
    John C Burnett, Jr
    Coadministration of B-Type natriuretic peptide and the Vasopressin-2 receptorantagonist tolvaptan: a novel physiologic strategy to enhance water and sodiumexcretion without adversely affecting renal or neurohumoral function in experimentalcongestive heart failure
  13. Gilberto De Nucci, Raquel Lorenzetti, Cristina E Okuyama, Juliana S Baracat, José L Donato, Edson Antunes, Cleber E Teixeira
    Pharmacological characterization of the novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum
  14. Matthias M Desch, Katja Sig, Beate Spiessberger, Dominik Bernhard, Angela Jochim, Jörg W Wegener, Franz Hofmann, Jens Schlossmann
    Analysis of smooth muscle function in IRAG knockout mice
  15. Ingeborg Dhaese, Gwen Vanneste, Robrecht Thoonen, Peter Brouckaert, Romain Lefebvre
    NO-induced motility effects in gastric fundus and pylorus of sGCß1his105phe mutantmice
  16. Jeffrey M Dodd-o, Maria L Hristopoulos, Jolanta Gutkowska, S Mukaddam-Daher, K Kibler, A Gonzalez, David B Pearse
    Reperfusion lung injury is attenuated by natriuretic peptide receptor antagonist in in- vivo mouse model
  17. Elisabeth Eder, Martin van Eickels, Stefan Frantz, Katharina Völker, Hideo A Baba, Michaela Kuhn
    Chronic inhibition of cyclic GMP phosphodiesterase 5A may promote pressure overload-induced chamber dilatation in mice
  18. Vicente Felipo, Blanca Piedrafita, Amparo Urios, Miguel A. Serra, A. del Olmo, José M Rodrigo, Carmina Montoliu
    Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients
  19. Haroldo A Flores Toque, Fernanda BM Priviero, Cleber E Teixeira, Edson Antunes, Gilberto de Nucci
    Effect of new sildenafil analogues in the rabbit isolated aorta
  20. Reiner Frey, Wolfgang Mück, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann, Georg Wensing
    BAY 63-2521, an oral soluble guanylate cyclase stimulator, has a favourable safety profile and decreases peripheral vascular resistance in healthy male volunteers
  21. Reiner Frey, Wolfgang Mück, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann, Georg Wensing
    BAY 58-2667, a soluble guanylate cyclase activator, has a favourable safety profile and reduces peripheral vascular resistance in healthy male volunteers
  22. Andreas Friebe, Dieter Groneberg, Peter König, Doris Koesling
    Physiological and pathological effects of complete sGC deletion
  23. Angeles Garcia-Pascual, Maria Sancho, Gonzalo Costa, Domingo Triguero
    Interstitial cells of Cajal in the urethra as effectors of the nitric oxide action through the cyclic GMP pathway
  24. Dieter Groneberg, Doris Koesling, Andreas Friebe
    Lack of NO-mediated NANC relaxation in mice deficient in NO-sensitive guanylyl cyclase
  25. Michael G Hahn, Cristina Alonso-Alija, Friederike Stoll, Markus Heil, Joachim Mittendorf, Karl-Heinz Schlemmer, Frank Wunder, Johannes-Peter Stasch
    Design and synthesis of the first NO- and haem-independent sGC activator
    BAY 58-2667 for the treatment of acute decompensated heart failure
  26. Michael Hartmann, Juliane Schröter, Viacheslav O Nikolaev, Albert Sickmann, Ruey-Bing Yang, Michaela Kuhn
    Characterization of an epitope-tagged guanylyl cyclase-A receptor
  27. Stefan Heitmeier, Ute Schüssler, Wolfgang Schröter, Nils Burkhardt
    A luminescence based biochemical assay for soluble guanylyl cyclase
  28. Michael Hoffmann, Uwe Thuss
    Cardiovascular effects of the soluble guanylyl cyclase activator
    BAY 58-2667 in anesthetized dogs
  29. Bernd Hohenstein, Christoph Daniel, Sandra Wittmann, Andrea Braun, Johannes-Peter Stasch, Christian Hugo
    Increased mesangial cGMP levels prevent mesangial cell proliferation and matrix expansion in experimental glomerulonephritis
  30. Brenda K Huntley, John C Burnett, Jr.
    Integrin receptor subtype antagonism augments BNP-Mediated cGMP generation in cultured human cardiac fibroblasts: evidence for particulate guanylate cyclase receptor and integrin receptor cross-talk
  31. Jennifer C Irvine, Barbara K Kemp-Harper, Robert E Widdop
    The nitroxyl anion (HNO) donor, Angeli’s salt, does not develop tolerance in vivo
  32. Jacques F Kameni-Tcheudji, Thérčse Keravis, Alain Le Bec, Luc Lebeau, Jean-Marie Strub, Alain van Dorsselaer, Claire Lugnier
    Vascular smooth muscle PDE5 is much more sensitive to N-alkylated zaprinast than platelet PDE5
  33. Lida Kimmel, Wendy Adamowicz, Mary Collins, Robin Kleiman
    Inhibitors of cAMP and cGMP phosphodiesterases enhance neurite outgrowth from cultured cortical neurons in a PKG dependent manner
  34. Tatjana Kostic, Marija Janjic, Natasa Stojkov, Stanko Stojilkovic, Silvana Andric
    cGMP-Protein kinase G signaling pathway is involved in stimulation of Leydig cell steroidogenesis
  35. Thomas Krieg, Ole Maas, Ulrike Donat, Stephan B Felix
    Vardenafil limits infarction at reperfusion in isolated rat hearts dependent on guanyly cyclase and PKG
  36. Lars S Kruse, Morten Mřller, Maiken Tibćk, Steen Gammeltoft, Jes Olesen, Christina Kruuse
    DE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system: role in pathogenesis of migraine?
  37. Candace YW Lee, Guido Boerrigter, Gail J Harty, John C Burnett, Jr
    Cardiorenal actions of a novel chimeric natriuretic peptide, CD-NP, as compared to
    C-type natriuretic peptide, in the normal dog
  38. Candace YW Lee, Guido Boerrigter, Gail J Harty, John C Burnett, Jr.
    Pharmacokinetic and pharmacodynamic study of a novel chimeric natriuretic peptide, CD-NP, in the normal dog
  39. Sivakkanan Loganathan, Tamás Radovits, Iwan R. Wirotanseng, Gábor Veres, Siegfried Hagl, Gábor Szabó
    Effects of vardenafil, a selective phosphodiesterase-5-inhibitor, on cardiovascular function in a rat model
  40. Emil Martin, Elena Bogatenkova, Ka Bian, Marie-Francoise Doursout
    Fresh look on old substances - new class of NO-independent regulators of soluble guanylyl cyclase activiy and function
  41. Fabiola Mónica, Gilberto de Nucci, Alice Bricola, Angelina Zanesco, Catarina Porto, Fernando Abdalla, Leandro Freitas, Maria Aparecida Teixeira, Edson Antunes
    Supersensitivity of muscarinic receptors in rat isolated detrusor smooth muscle (DSM) after chronic nitric oxide inhibition
  42. Michael Nesheim, John Samis, John Walker, Timothy Fischer, Liliana Tejidor, Greg Jones, Wim Houdijk, Alan Giles, Lev Becker, Marlys Koschinsky, Richard Wenstone, Colin Downey, Cheng Hock Toh
    The formation of a Ca2+-dependent complex of C-reactive protein and very low densitylipoprotein causes the biphasic transmittance waveform
  43. Viacheslav O Nikolaev, Sabine Herget, Martin J Lohse
    FRET-based method for rapid screening of PDE-inhibitors in living cells
  44. Catherine M Panayiotou, Adrian J Hobbs
    NPR-A gene deletion reverses vascular dysfunction associated with sepsis
  45. Andreas Papapetropoulos, Zongmin Zhou, Nazish Sayed, Anastasia Pyriochou, Charis Roussos, David Fulton, Annie Beuve
    Protein kinase G phosphorylates soluble guanylyl cyclase and inhibits its activity
  46. Cindy Paul, Pascal Weinmeister, Robert Fei, Franz Hofmann, Thomas Kleppisch
    cGMP-dependent kinase I supports formation of associative fear memory and long-term potentiation in the lateral amygdala
  47. Anastasia Pyriochou, Zongmin Zhou, Andreas Papapetropoulos
    cGMP-dependent and -independent angiogenesis-related properties of nitric oxide
  48. Peter Sandner, Hanna Tinel, Beatrix Stelte-Ludwig, Erwin Bischoff, Joachim Huetter
    The use of PDE5 inhibitors in the treatment of benign prostate hyperplasia and lower urinary tract symptoms: preclinical evidences
  49. Nazish Sayed, David Kim, Walter N Durán, Annie Beuve
    S-nitrosylation of soluble guanylyl cyclase: a novel mechanism of nitrate tolerance?
  50. Nazish Sayed, Padmamalini Baskaran, Focco van den Akker, Annie Beuve
    Desensitization of soluble guanylyl cyclase, the NO-receptor, by S-nitrosylation
  51. EP Schmidt, AJ Gonzales, LE Servinsky, JM Dodd-o, David B Pearse
    Increased ventilatory lung stretch alters the effect of soluble guanylyl cyclase-derived cGMP on endothelial barrier function in isolated mouse lungs
  52. Achim Schmidtko, Wei Gao, Matthias Sausbier, Inga Grundei, Ellen Niederberger, Klaus Scholich, Andrea Huber, Hans-Dieter Allescher, Franz Hofmann, Peter Ruth, Gerd Geisslinger
    Cysteine-rich protein 2 is a downstream effector of cGMP-dependent protein kinase I in nociception
  53. Barbara Schreier, Birgit Gaßner, Katharina Völker, Stepan Gambaryan Michaela Kuhn
    ANP changes microvascular endothelial barrier function in vivo
  54. Raphaela Schwappacher, Joerg Weiske, Verena Ezerski, Sylke Hassel, Otmar Huber, Petra Knaus
    Cyclic GMP-dependent kinase I promotes BMP signaling
  55. Iraida G Sharina, Emil Martin, Elena P Bogatenkova, VG Sharin, Ferid Murad
    New human alpha1 soluble guanylyl cyclase splice variants as potential regulators of sGC activity
  56. Albert Smolenski, Meike Hoffmeister, Pavel Riha, Olga Neumüller, Oliver Danielewski, Jan Schultess
    cGMP-dependent protein kinase regulates Rap1 signaling in platelets
  57. Gábor Szabó, Gábor Veres, Tamás Radovits, Christiane Miesel-Gröschel, Matthias Karck
    Vardenafil improves myocardial and endothelial function after cardiopulmonary bypass
  58. Cleber E Teixeira, Fernanda BM Priviero, R Clinton Webb
    Effects of BAY 41-2272 on smooth muscle tone, soluble guanylyl cyclase activity and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal and endothelial NOS null mice
  59. Ranji Thomas, Jane Fisher, Richard Heppell, Nigel Brayshaw , Sarah Cluck, Claire Gilbert, Ghazwan Butrous, Kayvan Kamalvand
    The effects of chronic sildenafil therapy in patients with stable systolic heart failure
  60. Robrecht Thoonen, Emmanuel Buys, Patrick Sips, Sofie Nimmegeers, Maureen Van den Hemel, Tino Hochepied, Johan Van de Voorde, Peter Brouckaert
    Targeting the NO – cGMP pathway: phenotyping of NO-insensitive sGCbeta1 H105F knockin mice
  61. Harukuni Tokuda, Junko Takayasu, Akira Iida
    Ultraviolet B light initiating activity of two-stage mouse skin carcinogenesis and its regulation of cGMP
  62. Nadejda Valtcheva, Pascal Weinmeister, Franz Hofmann, Susanne Feil, Robert Feil
    Analysis of cGKI inhibition by Rp-cGMP analogs
  63. Yingrui Wang-Rosenke, Stephanie Krämer, Tanja Loof, Sebastian Martini, Dmytro Khadzhynov, Eva Binder, Hans-Hellmut Neumayer, Harm Peters
    Activation of the nitric oxide-cGMP signaling pathway precedes resolution in acute anti-thy1 glomerulonephritis
  64. Pascal Weinmeister, Robert Lukowski, Cornelia Traidl-Hoffmann, Stefan Linder, Franz Hofmann, Robert Feil
    Activation of the cGMP/cGKI signalling pathway in primary murine VSMCs accelerates growth
  65. Matthias E Werner, Andrea L Meredith, Richard W Aldrich, Mark T Nelson
    Hyper-contractility and impaired cGMP signaling in the BKCa channel deletion model oferectile dysfunction
  66. Frank Wunder, Guido Buehler, Jörg Hüser, Stefan Mundt, Martin Bechem, Bernd Kalthof
    A luminescence-based assay for sensitive nitric oxide detection
  67. Angelina Zanesco, Camila de Moraes, AP Dave , LV Rosson, Gilberto de Nucc, Edson Antunes
    Exercise training effects on vascular reactivity and metabolic parameters of high caloric-fed Wistar rats
  68. Tong Zhang, Shunhui Zhuang, Darren E Casteel, Renate B Pilz
    A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase
  69. Zongmin Zhou, Anastasia Kotanidou, Charis Roussos, Andreas Papapetropoulos
    Activation of soluble guanylyl cyclase (sGC) by the NO/heme-independent activator HMR1766 in cells