9th International Conference on cGMP


cGMP: Generators, Effectors and
Therapeutic Implications

Pre-final program

Friday, June 14, 2019

13:00-13:55 Registration & Welcome Reception
13:55 Harald Schmidt,
Maastrich
Welcome to Mainz
S1 | Session 1:
Clinical Translation 
Chairs:
Peter Brouckaert, Gent
Johannes-Peter Stasch, Wuppertal
S1-01 14:00 Mark T. Gladwin,
Pittsburgh
NO-sGC signaling and therapeutics in sickle cell and hemolytic diseases
S1-02 14:20 Christopher Winrow,
Boston
Evaluating soluble guanylate cyclase stimulation for serious central nervous system diseases
S1-03 14:40 Melanie Hemmrich,
Wuppertal
Efficacy and safety of riociguat in patients with early diffuse cutaneous systemic sclerosis: Results from the RISE-SSc study, a randomized, double-blind, placebo-controlled phase IIb study
S2 | Session 2:
Non-canonical signaling and PKG
Chairs:
Jens Schlossmann, Regensburg
Franz Hofmann, München
S2-01 15:00 David Baker,
London
Targeting the Plasmodium falciparum cyclic GMP-dependent protein kinase to combat malaria
S2-02 15:20 Friedrich W. Herberg,
Kassel
A unique activation mechanism for Plasmodium falciparum PKG
S2-03 15:40 Dominique Soldati-Favre,
Geneva
“Prison Break”: Toxoplasma gondii egress from infected cells is a programmed event governed by a lipid mediator via a guanylate cyclase receptor platform
16:00–16:30 COFFEE BREAK
 
S2-04 16:30 Friederike Cuello,
Hamburg
Redox-regulation of protein kinase G in the cardiovascular system
S2-05 16:50 Thomas M. Moon,
Tucson
Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase
S2-06 17:05 Choel Kim,
Houston
Crystal structure of PKG Iß holoenzyme reveals a trans-inhibiting dimer assembly
ML | Murad Lecture Chair:
Ferid Murad, Washington DC
ML-01 17:20 Ferid Murad,
Washington DC
Introduction
 
ML-02 17:25-18:15 David. A. Kass,
Baltimore
GC/PDE crosstalk in the heart
18:15-21:30 SNACKS, WINE AND BEER
  Poster Session 1

Saturday, June 15, 2019

 
S3 | Session 3:
The natriuretic peptide pathway 
Chairs:
Finn Olav Levy, Oslo
Michaela Kuhn, Würzburg
S3-01 08:30 John Burnett,
Rochester
Designer ANP mimetic for hypertension
S3-02 08:50 Michaela Kuhn,
Würzburg
Paracrine cyclic GMP-mediated anti-inflammatory actions of C-type natriuretic peptide
S3-03 09:10 Viacheslav O. Nikolaev,
Hamburg
cGMP microdomains regulate natriuretic receptor signalling in cardiac myocytes
S3-04 09:30 David Paterson,
Oxford
NP/NO regulation of cardiac sympathetic drive
S3-05 09:50 Robert M. Blanton,
Boston
Sacubitril/valsartan improves LV function in chronic pressure overload independently of intact cGMP-dependent protein kinase I alpha signaling
10:05-10:35 COFFEE BREAK
 
S4 | Session 4:
Potential new applications
Chairs:
Philip Eaton, London
Peter Sandner, Wuppertal
S4-01 10:35 Jerid Robinson,
Minneapolis
Guanylyl cyclase-A activation decreases heart size and adiposity in male mice
S4-02 10:50 Lukas Rüttiger,
Tübingen
A role of the guanylyl cyclase GC-A in auditory function
S4-03 11:05 James R. Klinger,
Providence
Role of natriuretic peptide receptors in pulmonary vascular endothelial function
S4-04 11:20 Philipp Henning,
Kassel
Mutation in cGMP-dependent protein kinase isoform Iα is associated with aortic root dilation and aneurism formation in patients, potentially due to altered kinase activity and cGMP binding kinetics
S4-05 11:35 Justin Percival,
Miami
Soluble guanylate cyclase stimulation ameliorates skeletal and cardiac muscle dysfunction in an mdx model of Duchenne muscular dystrophy
11:50-13:30 SNACK AND REFESHMENTS
  Poster Session 2
 
13:45-15:45
MAINZ VISIT
Guided city walk through historic Mainz
 
15:45-17:30
CULTURAL PROGRAM
Organ concert at St Stephan´s church
17:30-17:45 COFFEE BREAK
 
S5 | Session 5:
cGMP network pharmacology
Chairs:
Doris Koesling, Bochum
Robert Feil, Tübingen
S5-01 17:45 Susan Taylor,
San Diego
Designing an allosteric switch: Lessons learned from PKA
S5-02 18:05 Michael Preedy,
London
Phosphodiesterase 2 promotes nitric oxide/guanylyl cyclase/cGMP signalling in heart failure
S5-03 18:25 Lise R. Moltzau,
Oslo
PDE3 inhibition drives a CNP/cGMP pathway to enhance cAMP signalling in HF
S5-04 18:45 Alexander Pfeifer,
Bonn
Rac1 – sGC/cGMP crosstalk in adipocytes and vascular smooth muscle
EL | Evening Lecture Chair:
Harald Schmidt, Maastricht
 
EL-01
19:05-19:55
Jan Baumbach, München What I learned from Arnold Schwarzenegger about breast cancer and gene panels
20:00-22:00 BARBECUE DINNER

Sunday, June 16, 2019

 
S6 | Session 6:
NO-GC structure, modulators and function I
Chairs:
Miriam Cortese-Krott, Düsseldorf
Andreas Friebe, Würzburg
S6-01 08:30 Harald Schmidt,
Maastricht
A revised pharmacology of sGC
S6-02 08:50 Wiliam Montfort,
Tucson
How stimulator compounds and nitric oxide bind and stimulate soluble guanylyl cyclase (GC1)
S6-03 09:10 Michael Marletta,
Berkeley
Structural aspects of sGC activation
S6-04 09:30 Doris Koesling,
Bochum
News within NO/cGMP signalling
S6-05 09:50 Florian Sohler,
Wuppertal
Dissection of particulate and soluble guanylyl cyclase pathways based on human genetics
10:05-10:35 COFFEE BREAK
 
S7 | Session 7:
NO-GC structure, modulators and function II
Chairs:
Robert Lukowski, Tübingen
Emmanuel Buys, Boston
S7-01 10:35 Juli Jones,
Boston
Praliciguat, a clinical-stage sGC stimulator, improved insulin sensitivity, lipid tolerance and energy utilization in a diet-induced obesity mouse model
S7-02 10:55 Miriam Cortese-Krott,
Düsseldorf
The NO-cGMP pathway in red blood cells
S7-03 11:15 Nikolaus Plesnila,
München
Inhaled nitric oxide as a therapeutic strategy for neurological disorders
S7-04 11:35 Fumito Ichinose,
Boston
Role of plasma NO consumption and sGC signalling in cardiac arrest and CPR
S7-05 11:55 Dieter Groneberg,
Würzburg
Function of pericytes during organ fibrosis
S7-06 12:10 Kjetil Andresen,
Oslo
New FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
12:25-14:30 SNACK AND REFESHMENTS
  Poster Session 3
S8 | Session 8:
Phosphodiesterases
Chairs:
Viacheslav O. Nikolaev, Hamburg
Achim Schmidtko, Frankfurt
S8-01 14:30 Gary A. Piazza,
Mobile
Novel PDE10 inhibitors with anticancer activity that suppress Wnt-induced β-catenin transcription by activating cGMP/PKG signaling
S8-02 14:50 Frank S. Menniti,
Groton
Phosphodiesterase 9A regulates nitric-oxide-independent cGMP signaling in brain
S8-03 15:10 Chen Yan,
Rochester
PDE10A-cGMP signaling and pathological vascular remodeling
15:30-16:00 COFFEE BREAK
 
S9 | Session 9:
Poster Presentations 
Chairs:
Werner Müller-Esterl, Frankfurt
Annie Beuve, Newark
16:00-17:00 6 selected posters 5 minute rapid fire oral presentations of selected posters
17:00–18:00 ORAL & POSTER PRIZE COMMITTEE MEETINGS
19:00–23:00 AWARD DINNER & CEREMONY


home | scientific organizers | program | further information | abstracts | registration | events | sponsors | impressum | privacy