10th International Conference on cGMP


cGMP: Generators, Effectors and
Therapeutic Implications

Pre-final Program (last updated: May 09, 2022)

Friday, June 17, 2022

13:00-13:55 Registration & Welcome Reception
13:55 Harald Schmidt,
Maastricht
Welcome to Augsburg
S1 | Session 1:
Pre-Clinical Translation & Back-Translation
Chairs:
Doris Koesling, Bochum
Franz Hofmann, Munich
S1-01 14:00 Chris Winrow,
Cambridge
Applying translational approaches for the nonclinical and clinical evaluation of the sGC stimulator CY6463 in CNS diseases
S1-02 14:20 Jos Prickaerts,
Maastricht
sGC modulators as cognitive enhancers: neuronal and/or vascular?
S1-03 14:40 Peter Sandner,
Wuppertal
Discovery and preclinical profiling of the oral sGC activator runcaciguat (BAY 1101042): A novel and effective treatment approach for chronic kidney disease?
S1-04 15:00 Cristian Nogales Calvo,
Maastricht
From phenotype to endotype: Preclinical validation of ROS-cGMPopathies in the Estonian Biobank
15:15-15:35 COFFEE BREAK
S2 | Session 2:
Brain & Neurosensory System
Chairs:
Marlies Knipper, Tübingen
Noelle L'Etoile, San Fransico
S2-01 15:35 Doris Koesling,
Bochum
Role of NO-GC1 and NO-GC2 in hippocampal cGMP responses induced by glutamatergic agonists
S2-02 15:55 Maya Shelly,
Stony Brook
A localized scaffold for cGMP increaseis required for apical dendrite development in embryonic principal neurons
S2-03 16:15 Yang Jian,
New York
Structural basis of CNG channel function and channelopathy
S2-04 16:35 Morgan Hess,
Tübingen
Stress affects central compensation of neural responses to cochlear synaptopathy in a cGMP-dependent way
16:50–17:00 Group PICTURE
17:00–18:30 POSTER SESSION I
18:30–19:45 SNACK AND REFESHMENTS
EL | Evening Lecture Chair:
Harald Schmidt, Maastricht
EL-01
19:45-20:30
Christoph Maack,
Würzburg
Metabolic and redox dysregulation in heart failure
20:30–22:00 POSTER SESSION II

Saturday, June 18, 2022

S3 | Session 3:
Clinical Translation / Cardiovascular
Chairs:
Peter Sandner, Wuppertal
Harald Schmidt, Maastricht
S3-01 08:30 Thomas Lüscher,
London
Lumpers and splitters: The legacy and future of heart failure management
S3-02 08:50 Paul Armstrong,
Edmonton
Travels with Vericiguat: Insights from a Clinical Scientist
S3-03 09:10 Torsten Kessler,
Munich
Genetic variation affecting cGMP signaling in atherosclerosis and myocardial infarction
S3-04 09:30 Dawood Darbar,
Chicago
Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model
S3-05 09:50 Andreas Busch,
Cambridge
Elderly, postmenopausal females with heart failure with preserved ejection fraction (HFpEF) are responsive to soluble guanylate cyclase (sGC) stimulation: A post hoc analysis of the CAPACITY trial.
10:10-10:30 COFFEE BREAK
S4 | Session 4:
Cardiovascular Diseases and cGMP
Chairs:
Robert Lukowski, Tübingen
Lise Román Moltzau, Oslo
S4-01 10:30 Friederike Cuello,
Hamburg
Nitroxyl induces blood pressure lowering in part by oxidation of cGMP-dependent protein kinase I
S4-02 10:50 Robert Blanton,
Boston
cGMP-dependent protein kinase I alpha substrates in the regulation of left ventricular function
S4-03 11:10 David A. Kass,
Baltimore
PDE9 inhibition for the treatment of obesity and cardiometabolic syndrome
S4-04 11:30 Viacheslav O. Nikolaev,
Hamburg
Illuminating local cGMP signaling for better cardioprotection
S4-05 11:50 Dulasi Arunthavarajah,
Oslo
Long term delivery of CNP in a mouse model of heart failure with preserved ejection fraction
12:10–13:15 SNACK AND REFESHMENTS
  POSTER SESSION III
13:15-17:00 NETWORKING / SCIENTIFIC EXCHANGE / DISCUSSION OF FRONTIER RESEARCH
17:00-17:20 COFFEE BREAK
S5 | Session 5:
Other Indications & Non-canonical Signaling
Chairs:
Miriam Cortese-Krott, Düsseldorf
Friederike Cuello, Hamburg
S5-01 17:20 Sheila Collins,
Nashville
New aspects of NP/cGMP signaling in adipocytes and energy expenditure
S5-02 17:40 Stylianos Michalakis,
Munich
Retinopathy caused by dysfunction of cGMP effectors
S5-03 18:00 Renate Pilz,
San Diego
Protein Kinase G2 Is Required for Androgen Receptor Signaling in Bone
S5-04 18:20 Benjamin Morehouse,
Boston
Cyclic CMP and cyclic UMP in bacterial immunity
S5-05 18:40 Peter van Haastert,
Groningen
Understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis in Dictyostelium
19:00–20:00 SNACK AND REFESHMENTS
AL | Anniversary Lecture Chair:
Hans-Peter Stasch, Munich
AL-01
20:00-20:45
Michael Marletta,
Berkeley
draft title: NO-GC - lessons learned
20:45-22:00 POSTER SESSION IV


Sunday, June 19, 2022

S6 | Session 6:
NO-GC Structure, Modulators, Function
Chairs:
Michael Marletta, Berkeley
Andreas Friebe, Würzburg
S6-01 08:30 Dennis J. Stuehr,
Cleveland
sGC maturation to function: Its mechanism, regulation, dynamics, and biological relevance
S6-02 08:50 Sönke Behrends,
Braunschweig
A potential role of GUCY1A2 the human gene encoding the α2-subunit of nitric oxide sensitive guanylyl cyclase in cancer
S6-03 09:10 Juan M. Redondo,
Madrid
NO–GC–PRKG signaling in Marfan syndrome
S6-04 09:30 Annie Beuve,
Newark
Soluble guanylyl cyclase, in addition to cGMP production, mediates NO signaling by using thioredoxin as a nitrosothiol relay under oxidative stress
09:50-10:10 COFFEE BREAK
S7 | Session 7:
Emerging Fields
Chairs:
Sheila Collins, Nashville
Jens Schlossmann, Regensburg
S7-01 10:10 Daniel Rowland,
Bonn
Compartmentation of cGMP in Adipocytes
S7-02 10:25 Aleksandra Dugandžić,
Zagreb
Uroguanylin activation of brown adipose tissue is age, gender, and phase of the estrous cycle dependent
S7-03 10:40 Rebecca H. Ritchie,
Melbourne
Therapeutic Implications of Nitroxyl (HNO) Donors as a Means of Enhancing cGMP-Mediated Cardioprotection in the Insulin-Resistant Diabetic Myocardium
S7-04 11:55 Lennart Kreutz,
Boston / Würzburg
Origin of NO-GC-positive activated fibroblasts and the role of NO-GC in angiotensin II-induced heart failure
S7-05 12:10 Melanie Cruz Santos,
Tübingen
Angiotensin II-induced cardiac fibrosis is attenuated by myofibroblast-specific cGKI
S7-06 12:25 Gaia Calamera, Oslo Natriuretic peptides increase cGMP around cardiomyocyte mitochondria and protect against apoptosis
12:25-13:30 SNACK AND REFESHMENTS
  POSTER SESSION V
S8 | Session 8:
Natriuretic Peptides and Receptors
Chairs:
Renate Pilz, San Diego
Michaela Kuhn, Würzburg
S8-01 13:30 Jens P. Goetze,
Copenhagen
Quantification of natriuretic peptides beyond post-translational modification
S8-02 13:50 Swati Dabral,
Würzburg
C-type natriuretic peptide - cGMP signalling attenuates hyperproliferation of lung pericytes from patients with Pulmonary Hypertension
S8-03 14:10 Lincoln Potter,
Minneapolis
Phosphoryl-regulation of receptor guanylyl cyclases: from chemical discovery to physiologic signalling
S8-04 14:30 Cristina Perez-Ternero,
London
C-type natriuretic peptide regulates metabolic homeostasis
14:50-15:10 COFFEE BREAK
S9 | Session 9:
Technological Advances & New Applications
Chairs:
Robert Lukowski, Tübingen
Peter Sandner, Wuppertal
S9-01 15:10 Noelle L'Etoile,
San Fransico
What happens in the cilia stays in the cilia, or localized cGMP fluxes in C. elegans sensory neurons
S9-02 15:30 Xavier Nicol,
Paris
Controlling cGMP downstream signaling with cellular and subcellular specificity using SponGee
S9-03 15:50 Eva-Maria Becker-Pelster,
Wuppertal
The sGC Activator inhale Mosliciguat (BAY 1237592): A new chapter in Pulmonary Hypertension Therapy via Activation of Apo-sGC
S10 | Session 10:
Poster Presentations “Rapid Fire”
Chairs:
Robert Blanton, Boston
Dennis J. Stuehr, Cleveland
16:10-16:40 5 minute rapid fire oral presentations of selected posters (3-5 selected posters)
16:40-17:30 ORAL & POSTER PRIZE COMMITTEE MEETING
19:00-23:00 AWARD DINNER & CEREMONY

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