cGMP: Generators, Effectors and
Therapeutic Implications
Preliminary program
Friday, June 23, 2017
| 13:00-14:00 | Registration & Welcome Reception | |
| 14:00 | Franz Hofmann, München |
Welcome to Bamberg |
| Session 1 Therapeutic Breakthroughs |
Chairs: Harald Lapp, Erfurt Johannes-Peter Stasch, Rome |
|
| 14:10 | Todd Milne, Boston |
Characterization and development of next-generation sGC stimulators |
| 14:30 | Peter Sandner, Wuppertal |
sGC stimulators and the potential impact for the treatment of fibrotic diseases and systemic sclerosis |
| 14:50 | Steven Pullen, Ridgefield |
A soluble guanylate cyclase (sGC) activator is superior to a PDE5 inhibitor and a sGC stimulator in protecting from diabetic nephropathy in the ZSF1 rat |
| 15:10 | Henriette Andresen, Oslo |
Identification and characterization of positive allosteric modulators of the natriuretic peptide receptor-A |
| 15:25–15:55 | COFFEE BREAK | |
| Session 2: cGMP signalling in cell growth and survival |
Chairs: Robert Feil, Tübingen Renate Pilz, San Diego |
|
| 15:55 | Emmanuel Buys, Boston |
GC-1 in glaucoma and retinal neuroprotection |
| 16:15 | Robert Lukowski, Tübingen |
Cardioprotective actions of the cGMP pathway in ischemia and reperfusion injury |
| 16:35 | Laurinda Jaffe, Farmington |
Intercellular signalling via cGMP diffusion through gap junctions restarts meiosis in ovarian follicles |
| 16:55 | Andreas Friebe, Würzburg |
NO/cGMP signalling in cells ‘off the beaten track’ |
| 17:15 | Timothy Calamaras, Boston |
Mixed lineage kinase 3 (MLK3), a novel PKGIα substrate, prevents pressure overload-induced cardiac remodelling |
| Murad Lecture | Chair: Ferid Murad, Washington DC |
|
| 17:30 | Ferid Murad, Washington DC |
Introduction |
| 17:35–18:35 | Stefan Hell, Göttingen |
Optical microscopy: the resolution revolution |
| 18:35-21:30 Poster Session 1 |
SNACKS, WINE AND BEER | |
Saturday, June 24, 2017
| Session 3 Genetics |
Chairs: Michaela Kuhn, Würzburg Peter Brouckaert, Ghent |
|
| 08:45 | Scott Waldman, Philadelphia |
Caloric silencing of GUCY2C-hormone axes at the nexus of obesity and colorectal cancer |
| 09:05 | Jeanette Erdmann, Lübeck |
sGC and atherosclerosis: a genomic approach |
| 09:25 | Henning Gall, Giessen |
Whole genome sequencing of variants in GC-cGMP-PDE signalling in pulmonary hypertension |
| 09:45 | Ulrich Walter, Mainz |
The human platelet phosphoproteome after sGC stimulation by Riociguat |
| 10:00-10:35 | COFFEE BREAK | |
| Session 4 Presentations based on abstract submission |
Chairs: David Kass, Baltimore Robert Lukowski, Tübingen |
|
| 10:35 | Ying-Chi Chao, Taipei |
Guanylate cyclase-G is an alarm pheromone receptor in mice |
| 10:50 | James Klinger, Providence |
The relationship between NO pathway biomarkers and response to riociguat in the RESPITE study of patients with PAH not reaching treatment goals with phosphodiesterase 5 inhibitors |
| 11:05 | Jaime Masferrer, Boston |
The soluble guanylate cyclase stimulator, IW-1973, is efficacious in models of NASH and liver fibrosis |
| 11:20 | Dorit Möhrle, Tübingen |
NO-sensitive guanylate cyclase isoforms NO-GC1 and NO-GC2 contribute to noise-induced inner hair cell synaptopathy |
| 11:35 | Sabine Tauscher, Würzburg |
Cardiac natriuretic peptides improve pancreatic beta-cell function |
| 11:50 | Yasutake Tanaka, Osaka |
ANP-GC-A signalling protects against acute exacerbation of pulmonary fibrosis in mice |
| 12:05-13:30 | SNACK AND REFESHMENTS | |
| 13:30-14:30 | CHAMBER CONCERT BY THE BAMBERGER STREICHQUARTETT Karmeliterkloster |
|
| 14:30-16:30 | BAMBERG VISIT Guided city walk through historic Bamberg |
|
| 16:30-17:00 | COFFEE BREAK | |
| Session 5 Non-cannonical signalling |
Chairs: Ulrich Walter, Mainz Günter Schultz, Berlin |
|
| 17:00 | Vikas Kapil, London |
Inorganic nitrate and the enterosalivary circuit: an alternative pathway for NO delivery in cardiovascular disease |
| 17:20 | Nazareno Paolocci, Baltimore |
From Heaven to Heart: Nitroxyl (HNO) actions in the cardiovascular system |
| 17:40 | Philip Eaton, London |
Redox regulation of G-kinase |
| 18:00 | Adam Straub, Pittsburgh |
Cytochrome b5 reductase 3 regulates soluble guanylate cyclase heme iron redox state |
| 18:15-19:15 | SNACKS AND REFRESHMENTS | |
| Evening Lecture | Chair: Adrian Hobbs, London |
|
| 19:15 | Adrian Hobbs, London | Introduction |
| 19:20-20:00 | Johannes-Peter Stasch, Rome |
sGC stimulators and sGC activators: past, present and future |
| 20:00-21:30 Poster Session 2 |
WINE AND BEER | |
Sunday, June 25, 2017
| Session 6 G-Kinase structure and function |
Chairs: Philip Eaton, London Doris Koesling, Bochum |
|
| 08:30 | Choel Kim, Houston |
Structural Basis of Analog Specificity in PKG I and II |
| 08:50 | Sonja Dames, München |
Insights in the regulation of mycobacterial G-kinase by redox changes, phosphorylation and membrane interactions by NMR |
| 09:10 | Nazha Hamdani, Bochum |
Titin as a promising target for cGMP/G-kinase and its potential role in heart failure |
| 09:30 | Robert Blanton, Boston |
Cardiac myosin binding protein-C as a substrate for G-kinase |
| 09:50 | Andrew Tobin, Glasgow |
Employing chemical genetics to determine the cellular targets for G-kinase in malaria |
| 10:10 | Olena Rudyk | Oxidation of cGMP-dependent protein kinase Iα in the lung during chronic hypoxia mediates an endogenous adaptation to pulmonary hypertension |
| 10:25-10:55 | COFFEE BREAK | |
| Session 7 Natriuretic peptides |
Chairs: Franz Hofmann, München Sönke Behrends, Braunschweig |
|
| 10:55 | Amie Moyes, London |
C-type natriuretic peptide regulates cardiac structure & function |
| 11:15 | Stuart Bunting, San Francisco |
NEP resistant CNP for bone growth disorders |
| 11:35 | Michaela Kuhn, Würzburg |
Vascular roles of C-type natriuretic peptide/cyclic GMP signaling |
| 11:55 | Konstanze Michel, Würzburg |
C-type natriuretic peptide: a friend of the heart |
| 12:10-13:40 Poster Session 3 |
SNACK AND REFESHMENTS | |
| Session 8 Phosphodiesterases |
Chairs: Harald Schmidt, Maastricht Andreas Friebe, Würzburg |
|
| 13:40 | Stylianos Michalakis, München |
Gene therapy for CNGA3-linked achromatopsia: from mouse models to clinical trials |
| 14:00 | David Kass, Baltimore |
Novel role of PKG in Protein Quality Control by Regulating CHIP |
| 14:20 | Manuela Zaccolo, Oxford |
PDE/cAMP regulation of cardiac hypertrophy |
| 14:40 | Rodolphe Fischmeister, Paris |
PDE2 regulation of cGMP/cAMP crosstalk in the myocardium |
| 15:00 | Michael Russwurm, Bochum |
Real-time measurements of cGMP in cardiac, neuronal and renal cells |
| 15:20 | Nadja Bork, Hamburg |
Changes in cardiomyocyte cGMP dynamics during hypoxia/re-oxygenation |
| 15:35-16:05 | COFFEE BREAK | |
| Session 9 Poster Presentation |
Chairs: Peter Sandner, Wuppertal Annie Beuve, Newark |
|
| 16:05–17:30 | 6 selected posters | 5 minute rapid fire oral presentations of selected posters |
| 17:30–18:00 | ORAL & POSTER PRIZE COMMITTEE MEETINGS | |
| 19:00–22:30 | AWARD DINNER & CEREMONY | |