cGMP: Generators, Effectors and
Therapeutic Implications
Pre-final Program (May 8, 2026)
Thursday, June 18, 2026
| 13:00-13:50 | Registration & Welcome Reception | |
| 13:50 | Friedrich W. Herberg, Kassel |
Welcome to Kassel |
| 13:55 | Franz Hofmann, München |
Welcome from the Leopoldina |
| S1 | Session 1: Clinical Translation: NP-based principles |
Chairs: Michaela Kuhn, Würzburg Franz Hofmann, München |
|
| S1-01 14:00 | Adam Snook, Philadelphia |
Prevention of Gastrointestinal Cancer Recurrence with GUCY2C-Directed Vaccines
|
| S1-02 14:20 | Lori Morton, Tarrytown |
REGN7544, an investigational first-in-class, fully human natriuretic peptide receptor 1-blocking monoclonal antibody for hypovolemic and hypotensive disorders
|
| S1-03 14:40 | Michael Nyberg, Copenhagen |
A Once-Weekly C-Type Natriuretic Peptide for Treatment of Heart Failure with Preserved Ejection Fraction
|
| S1-04 15:00 | Ana Calejo, Oslo |
Targeting resistant hypertension with allosteric modulator of GC‑A |
| 15:20-15:50 | COFFEE BREAK | |
| S2 | Session 2: Clinical Translation: NO-GC targeting drugs |
Chairs: Peter Sandner, Wuppertal Roland Seifert, Hannover |
|
| S2-01 15:50 | Stefano Corda, Basel |
Vericiguat, Victoria, Victor: sGC stimulator therapy in heart failure |
| S2-02 16:10 | Robert Lawatscheck, Berlin |
Efficacy and safety of the SGC activator Nurandociguat in patients with CKD: the phase 2b study ALPINE-1 |
| S2-03 16:30 | Ubaldo Martin, Waltham |
Development and clinical function of the inhaled sGC activator mosliciguat in PH
|
| S2-04 16:50 | Thorsten Leucker, Baltimore |
Targeting Impaired NO-sGC-cGMP Signaling With Vericiguat Improves Coronary Endothelial Function in Patients With Metabolic Syndrome or Type 2 Diabetes |
| S2-05 17:10 | Philipp Ellinger, Wuppertal |
Systematic analysis of disease-causing sGC mutations with sGC stimulators and sGC activators |
| 17:30-18:00 | GROUP PHOTO |
|
| 18:00-20:00 | GUIDED POSTER SESSION I (poster numbers 01-22) Chairs: Miriam Cortese-Krott and Peter Sandner |
|
| 19:00-21:00 | SNACKS AND REFRESHMENTS | |
| MML | Ferid Murad Memorial Lecture |
Chair: Miriam Cortese-Krott, Tübingen |
|
| MML-01 21:00-21:45 |
Lorenzo Berra, Boston |
Revisiting Inhaled Nitric Oxide: From Pulmonary Vasodilator to Targeted Pulmonary Therapy |
Friday, June 19, 2026
| S3 | Session 3: NO/ NO-GC regulation and functions |
Chairs: Andreas Friebe, Würzburg Annie Beuve, Newark |
|
| S3-01 09:00 | Dennis Stuehr, Cleveland |
Illuminating the Multi-step Maturation Process of sGC that Controls its Capacity for cGMP Production in Mammals |
| S3-02 09:20 | Michael Marletta, Berkeley |
The Influence of sGC Conformation on Stimulator Function |
| S3-03 09:40 | Daniela Wenzel, Bochum |
Beta arrestin 1 and sGC: Implications for pulmonary hypertension |
| S3-04 10:00 | Brant Isakson, Charlottesville |
Lymphatic endothelial alpha globin promotes cardiac hypertrophy and T cell accumulation in the heart during cardiometabolic heart failure |
| S3-05 10:20 | Chen Guang Wei, London |
Exploratory assessment of mechanisms of action of long-term inorganic nitrate supplementation in hypertensive patients with and without left ventricular hypertrophy |
| 10:40-11:10 | COFFEE BREAK | |
| S4 | Session 4: Rising stars in cGMP research |
Chairs: Peter Sandner, Wuppertal Robert Lukowski, Tübingen |
|
| S4-01 11:10 | Anthea Lo Bue, Tübingen |
Endothelial cell eNOS regulates sodium excretion in the kidney as determined in endothelial cell-specific eNOS KO and KI mice |
| S4-02 11:25 | Alexandra Fachinger, Kassel |
Isoform-Specific Modulation of PKG I Activity by the Small Molecule Inhibitor Rp-8-Br-PET-cGMPS: Elucidating the Mechanistic Roles of the Individual Cyclic Nucleotide Binding Domains |
| S4-03 11:40 | Rieke Wellpott, Regensburg |
Analysis of PKGI’s dynamic landscape using single-molecule FRET measurements |
| S4-04 11:55 | Katharina Paulus, Tübingen |
Proteomic analysis reveals potential new downstream interactors of the cardiac cGMP pathway under healthy and I/R conditions |
| 12:10-13:30 | POSTER SESSION II (all numbers) |
|
| 12:10-13:30 | SNACKS AND REFRESHMENTS | |
| 13:30-16:30 | FREE TIME | |
| 16:30-17:00 | COFFEE BREAK | |
| S5 | Session 5: Systemic and local effects of NP/NPR |
Chairs: Lise Roman Moltzau, Oslo Jens Schlossmann, Regensburg |
|
| S5-01 17:00 | Achim Schmidtko, Frankfurt |
CNP/Npr2 signaling in sensory neurons contributes to pain processing |
| S5-02 17:20 | Xin-Yun Huang, New York |
Structural biochemistry of activation of GC-A by hormone and therapeutic antibodies |
| S5-03 17:40 | Kristen J. Bubb, Melbourne |
C-type natriuretic peptide reduces blood pressure and restores placental angiogenesis in a mouse model of preeclampsia |
| S5-04 18:00 | Robert Rose, Calgary |
Natriuretic peptide dependent cGMP signaling in the heart protects against atrial remodeling, sinoatrial node dysfunction, and atrial fibrillation |
| S5-05 18:20 | Swati Dabral, Würzburg |
C-type natriuretic peptide – cyclic GMP Axis in Pulmonary Fibrosis: From Disease Mechanisms to Therapeutic Targeting |
| 18:40-19:45 | SNACKS AND REFRESHMENTS | |
| EL | Evening Lecture | Chair: Adrian Hobbs, London |
|
| EL-01 19:45-20:30 |
Michaela Kuhn, Würzburg |
A guided tour through long and short ANP-to-cyclic GMP circuits |
| 20:30-22:00 | GUIDED POSTER SESSION III (poster numbers 23-44) Chairs: Adrian Hobbs and Friedrich W. Herberg |
|
Saturday, June 20, 2026
| S6 | Session 7: CN crosstalk by PDE |
Chairs: Finn Olav Levy, Oslo Leila Gobejishvili, Louisville |
|
| S6-01 08:30 | Atsuhiko Ichimura, Kyoto |
PDE3 inhibition boosts CNP-stimulated bone growth through intracellular Ca2+ signaling |
| S6-02 08:50 | Jonathan C. Schisler, Chapel Hill |
PDE9A and cGMP/cAMP crosstalk as a target to restore mitophagy and prevent ataxia |
| S6-03 09:10 | Andrea M. Isidori, Rome |
Metabolic actions of PDE5i in the control of glucose and lipid metabolism |
| S6-04 09:30 | Kjetil W. Andressen, Oslo |
PDE regulation of mitochondrial cGMP |
| S6-05 09:50 | Melody Atkins, Paris |
Primary cilium-elicited cGMP and cAMP signals antagonise each other to regulate cell polarity during neuronal migration |
| 10:10-10:40 | COFFEE BREAK | |
| S7 | Session 7: Monitoring cGMP and PKG in action |
Chairs: Friedrich W. Herberg, Kassel Robert Lukowski, Tübingen |
|
| S7-01 10:40 | Jin Zhang, San Diego |
Illuminating the Dynamic Biochemical Activity Architecture of the Cell |
| S7-02 11:00 | Robert Feil, Tübingen |
Mechano-cGMP: A new mode of NO-cGMP signaling in the cardiovascular system |
| S7-03 11:20 | Friederike Cuello, Hamburg |
Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability to Cause Aortopathy: PRKG1 variants and inherited aortic disease |
| S7-04 11:40 | Giuseppe Melacini, Hamilton |
Mechanism of Protein Kinase G Allosteric Inhibitors with Therapeutic Potential in Retinal Degeneration |
| S7-05 12:00 | Akiyuki Nishimura, Okazaki |
TRPC6-mediated Zn2+ influx improves heart failure through PKG-mediated anti-fibrotic effect |
| 12:20-13:50 | POSTER SESSION IV (all numbers) | |
| 12:20-13:50 | SNACKS AND REFRESHMENTS | |
| S8 | Session 8: Non-canonical (cGMP-related) mechanisms |
Chairs: Miriam Cortese-Krott, Tübingen Brant Isakson, Charlottesville |
|
| S8-01 13:50 | Tohru Fukai, Augusta |
Exercise-induced SOD3-derived H2O2 Sulfenylates PKG1a to Restore cGMP-independent Vasodilation in type2 diabetes |
| S8-02 14:10 | Nagaraj Kerur, Columbus |
cGMP, cGAMP, and Beyond: Cyclic Dinucleotide Signaling from Phage to Physiology |
| S8-03 14:30 | Takaaki Akaike, Sendai |
Cyclo-octasulfur (S8): A potential signalling molecule produced by endothelial nitric oxide synthase |
| S8-04 14:50 | Annie Beuve, Newark |
Endothelial soluble guanylyl cyclase: resistance is not futile! |
| S8-05 15:10 | Adriana Szmidt-Jawrowska, Toruń |
Cyclic nucleotides in plants |
| 15:30-16:00 | COFFEE BREAK | |
| S9 | Session 9: Poster Presentations “Rapid Fire” |
Chairs: Sheila Collins, Nashville Michael Marletta, Berkeley |
|
| S9-01 16:00 | 3 to 5 selected posters from poster numbers 1-44 | 5 minute rapid fire oral presentations of selected posters |
| 16:50-18:00 | ORAL & POSTER PRIZE COMMITTEE MEETING | |
| 18:30-22:00 | AWARD DINNER & CEREMONY | |